In this chapter, de Boe introduces a methodological framework for a systematic assessment of the quality of remote interpreting and the effectiveness of the communication in dialogic healthcare settings, drawing on methods from both interpreting studies and medicine. Central to the research design is a corpus of simulations of interpreter-mediated doctor – patient encounters, performed in the modes face-to-face, telephone and video interpreting. These simulations were submitted to a comparative, multi-modal analysis, the results of which were triangulated with the subjective assessment by the participants. The author will first touch upon research issues and caveats relevant to remote healthcare interpreting, emerging from medical studies and interpreting studies. Subsequently, the research design of the present study will be elaborated, followed by a discussion of the preliminary findings of the first series of simulations. The first outcomes suggest that the use of technology in interpreter-mediated health care impacts mostly on the interactional dynamics of the communication.